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Test ID BFOS FosB, Immunostain, Technical Component Only


Ordering Guidance


This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.



Shipping Instructions


Attach the green pathology address label and the pink Immunostains Technical Only label included in the kit to the outside of the transport container.



Specimen Required


Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Container/Tube: Immunostains Technical Only Envelope

Preferred: 2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.

Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block


Useful For

Diagnosing pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma (PHE) and epithelioid hemangiomas

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOI IHC Initial, Tech Only No No
IHTOA IHC Additional, Tech Only No No

Method Name

Immunohistochemistry (IHC)

Reporting Name

FosB IHC, Tech Only

Specimen Type

TECHONLY

Specimen Stability Information

Specimen Type Temperature Time Special Container
TECHONLY Ambient (preferred)
  Refrigerated 

Clinical Information

FosB is a member of the Fos transcription factor family and a component of the activator protein-1 (AP-1) protein complex. Expressed in the nucleus, FosB is useful in the diagnosis of pseudomyogenic (epitheliod sarcoma-like) hemangioendothelioma (PHE) and may be helpful to distinguish it from its histologic mimics. FosB is also found in a subset of epithelioid hemangiomas.

Interpretation

This test does not include pathologist interpretation, only technical performance of the stain. If interpretation is required order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.

 

The positive and negative controls are verified as showing appropriate immunoreactivity. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request, call 855-516-8404.

 

Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Clinical Reference

1. Hung YP, Fletcher CD, Hornick JL: FOSB is a useful diagnostic marker for pseudomyogenic hemangioendothelioma. Am J Surg Pathol. 2017;41:596-606

2. Sugita S, Hirano H, Kikuchi N, et al:  Diagnostic utility of FOSB immunohistochemistry in pseudomyogenic hemangioendothelioma and its histological mimics. Diagn Pathol. 2016;11:75. doi 10.1186/s13000-016-0530-2

3. Huang SC, Zhang L, Sung YS, et al: Frequent FOS gene rearrangements in epithelioid hemangioma: A molecular study of 58 cases with morphologic reappraisal. Am J Surg Pathol. 2015;39(10):1313-1321

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BFOS FosB IHC, Tech Only Order only;no result

 

Result ID Test Result Name Result LOINC Value
603420 FosB IHC, Tech Only Bill only; no result

Forms

If not ordering electronically, complete, print, and send an Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.

Testing Algorithm

For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI). For each additional technical component only IHC stain performed, an additional bill-only test ID will be reflexed and charged (IHTOA).

Mayo Clinic Laboratories | IHC Catalog Additional Information:

mcl-ihc