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Test ID CAIX Carbonic Anhydrase IX (CA-IX) Immunostain, Technical Component Only


Ordering Guidance


This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.



Shipping Instructions


Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.



Specimen Required


Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Container/Tube: Immunostain Technical Only Envelope

Preferred: 2 unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.

Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block


Useful For

Diagnosis of clear cell renal cell carcinoma and clear cell papillary renal cell carcinoma

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOA IHC Additional, Tech Only No No
IHTOI IHC Initial, Tech Only No No

Method Name

Immunohistochemistry

Reporting Name

CAIX IHC, Tech Only

Specimen Type

TECHONLY

Specimen Stability Information

Specimen Type Temperature Time Special Container
TECHONLY Ambient (preferred)
  Refrigerated 

Clinical Information

Carbonic anhydrase IX (CA-IX) is a hypoxia-induced protein expressed in the gastrointestinal tract, mainly in the stomach. Expression of CA-IX is useful in the diagnosis of clear cell renal cell carcinoma and clear cell papillary renal cell carcinoma. It can assist in distinguishing clear cell carcinoma from chromophobe carcinoma, oncocytoma, and several other renal cell carcinomas.

Interpretation

This test does not include pathologist interpretation; only technical performance of the stain. If interpretation is required order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.

 

The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.

 

Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Clinical Reference

1. Alshenawy H: Immunohistochemical panel for differentiating renal cell carcinoma with clear and papillary features. J Microsc Ultrastruct. 2015;3(2):68-74

2. Genega E, Ghebremichael M, Najarian R, et al: Carbonic anhydrase IX expression in renal neoplasms: correlation with tumor type and grade. Am J Clin Pathol. 2010;134(6):873-879. doi: 10.1309/AJCPPPR57HNJMSLZ

3. Stillebroer A, Mulders P, Boerman O, Oyen WJG, Oosterwijk Eet al: Carbonic anhydrase IX in renal cell carcinoma: Implications for prognosis, diagnosis, and therapy. Euro Urol. 2010;58(3):75-83. doi: 10.1016/j.eururo.2010.03.015

4. Zhanyong B, Lal P, Lu S, Ziober A, Tomaszewski JEet al: Role of carbonic anhydrase IX, alpha-methylacyl coenzyme a racemase, cytokeratin 7, and galectin-3 in the evaluation of renal neoplasms: a tissue microarray immunohistochemical study. Annals of Diag Pathol. 2013;17(8) 58-62. doi: 10.1016/j.anndiagpath.2012.07.002

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CAIX CAIX IHC, Tech Only Order only;no result

 

Result ID Test Result Name Result LOINC Value
606252 CAIX IHC, Tech Only Bill only; no result

Forms

If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen. 

Mayo Clinic Laboratories | IHC Catalog Additional Information:

mcl-ihc