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Test ID CD10 CD10 Immunostain, Technical Component Only


Ordering Guidance


This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.



Shipping Instructions


Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.



Specimen Required


Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Container/Tube: Immunostain Technical Only Envelope

Preferred: 2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick

Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block


Useful For

Phenotyping leukemias and lymphomas

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOI IHC Initial, Tech Only No No
IHTOA IHC Additional, Tech Only No No

Method Name

Immunohistochemistry

Reporting Name

CD10 IHC, Tech Only

Specimen Type

TECHONLY

Specimen Stability Information

Specimen Type Temperature Time Special Container
TECHONLY Ambient (preferred)
  Refrigerated 

Clinical Information

CD10 is a cell surface glycoprotein present on bone marrow B precursors (hematogones) and myeloid cells (including neutrophils), follicle center B cells, and a subset of follicular T helper cells. CD10 is also expressed in the brush border of the upper part of the intestinal tract, bile canaliculi, kidney (glomerular and proximal tubular cells), pulmonary alveolar cells, myoepithelial cells of breast, prostate glandular cells, placental trophoblastic cells, endometrial stromal cells, some endothelial cells, and a minority of (myo-)fibroblasts (stromal cells). CD10 is most useful in the diagnosis of B-precursor-acute lymphoblastic leukemia, Burkitt lymphoma, and lymphomas of follicle cell center origin (follicular lymphoma, subset of large B-cell lymphomas).

Interpretation

This test does not include pathologist interpretation; only technical performance of the stain is performed. If an interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.

 

The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.

 

Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Clinical Reference

1. Al-Masri M, Darwazeh G, Sawalhi S et al: Phyllodes tumor of the breast: role of CD10 in predicting metastasis. Ann Surg Oncol. 2012;19:1181-1184. doi: 10.1245/s10434-011-2076-6

2. Taghizadeh-Kermani Ali, Jafarian AH, Ashabymin R, et al: The stromal overexpression of CD10 in invasive breast cancer and its association with clincophathologic factors. Iran J Cancer Prev. Winter 2014;7(1):17-21

3. Lloyd J, Owens S: CD10 immunohistochemistry stains enteric mucosa, but negative staining is unreliable in the setting of active enteritis. Mod Pathol. 2011;24:1627-1632. doi: 10.1038/modpathol.2011.122

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CD10 CD10 IHC, Tech Only Order only;no result

 

Result ID Test Result Name Result LOINC Value
70686 CD10 IHC, Tech Only Bill only; no result

Forms

If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.

Mayo Clinic Laboratories | IHC Catalog Additional Information:

mcl-ihc