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HelpTest ID CDKPB CD68 (KP1) Immunostain, Bone Marrow, Technical Component Only
Ordering Guidance
This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.
Shipping Instructions
Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.
Specimen Required
Specimen Type: Tissue
Supplies: Immunostain Technical Only Envelope (T693)
Container/Tube: Immunostain Technical Only Envelope
-Formalin-fixed, paraffin-embedded tissue block
OR
-2 Unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick
Acceptable: None
Forms
If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.
Useful For
Aiding in the identification of histocytic and myeloid lineage cells
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IHTOI | IHC Initial, Tech Only | No | No |
| IHTOA | IHC Additional, Tech Only | No | No |
Method Name
Immunohistochemistry (IHC)
Reporting Name
Bone Marrow CD68(KP1) IHC, T OnlySpecimen Type
TECHONLYSpecimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| TECHONLY | Ambient (preferred) | ||
| Refrigerated | |||
Clinical Information
In normal tissues, CD68 KP-1 stains the cytoplasm of the granulocytes and myeloid progenitors in the bone marrow, monocytes, and macrophages, and osteoclasts. KP-1 reacts against a carbohydrate moiety of CD68. Although CD68 KP-1 is primarily used as a histiocytic marker, it is not specific for histiocytes. It can also be expressed in malignant melanoma, granular cell tumors, peripheral nerve sheath tumors, malignant fibrous histiocytoma, and other mesenchymal neoplasms and rare carcinomas.
Interpretation
This test does not include pathologist interpretation, only technical performance of the stain. If interpretation is required order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.
The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.
Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Clinical Reference
1. Sanchez-Espiridion B, Martin-Moreno AM, Montalban C, et al: Immunohistochemical markers for tumor associated macrophages and survival in advanced classical Hodgkin's lymphoma. Haematologica. 2012 Jul;97:1080-1084
2. Tan KL, Scott DW, Hong F, et al: Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 Intergroup trial. Blood. 2012 Oct 18;120(16):3280-3287
3. Mehra N, Schnatiwinkel C, Ergon L, et al: Comparison of multiplexed imaging mass cytometry in FFPE tissue to monoplex immunohistochemistry. Tumor Biology. 2018;78(13):3037
Day(s) Performed
Monday through Friday
Report Available
1 to 3 daysTest Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
88342-TC, primary
88341-TC, if additional IHC
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CDKPB | Bone Marrow CD68(KP1) IHC, T Only | Order only;no result |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 603210 | Bone Marrow CD68(KP1) IHC, T Only | Bill only; no result |
mcl-ihc