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Test ID CRPRO C-Reactive Protein (CRP) Immunostain, Technical Component Only

Ordering Guidance

This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.

Shipping Instructions

Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.

Specimen Required

Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Container/Tube: Immunostain Technical Only Envelope

Preferred: 2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick

Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block

Useful For

Classification of hepatic adenomas

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOI IHC Initial, Tech Only No No
IHTOA IHC Additional, Tech Only No No

Method Name


Reporting Name

C Reactive Protein IHC, Tech Only

Specimen Type


Specimen Stability Information

Specimen Type Temperature Time Special Container
TECHONLY Ambient (preferred)

Clinical Information

C-reactive protein (CRP) is an acute-phase reactant associated with host defense that promotes agglutination and complement fixation. CRP can be used with a panel of immunohistochemical markers (beta-catenin, liver fatty acid-binding protein, glutamine synthetase, and amyloid A) to distinguish hepatic adenoma from focal nodular hyperplasia and non-neoplastic liver. CRP, along with amyloid A, is overexpressed in inflammatory (type 3) hepatic adenoma. CRP may stain hepatocytes in nonneoplastic liver tissue in areas of nonspecific inflammation.


This test does not include pathologist interpretation; only technical performance of the stain is performed. If an interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.


The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Clinical Reference

1. Ma Y, Lu M, Deng Y, et al: The Preparation of C-Reactive Protein Immunosensor Based on Nano-Mimetic Enzyme Co3O4. J Biomed Nanotechnol 2018;14(6):1169-1177

2. Wang M, Meng S, Gu M, et al: An Enzyme-Linked Immunosorbent Assay for C-Reactive Protein Based on Gold Nanoparticlesat Metal Porphyrin Porous Compound. J Biomed Nanotechnol 2019;15(10):2100-2107

3. Yeh Y, Lei H, Chen M, et al: C-Reactive Protein (CRP) is a Promising Diagnostic Immunohistochemical Marker for Intrahepatic Cholangiocarcinoma and is Associated with Better Prognosis. Am J Surg Pathol 2017;41(12):1630-1641

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CRPRO C Reactive Protein IHC, Tech Only Order only;no result


Result ID Test Result Name Result LOINC Value
70722 C Reactive Protein IHC, Tech Only Bill only; no result


If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.

Mayo Clinic Laboratories | IHC Catalog Additional Information: