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Test ID FC13A Factor 13a Immunostain, Technical Component Only


Ordering Guidance


This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.



Shipping Instructions


Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.



Specimen Required


Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Container/Tube: Immunostain Technical Only Envelope

Preferred: 2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick

Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block


Useful For

Aiding in the identification of acquired digital fibrokeratomas, angiofibromas, and oral fibroma, and a proportion of cells in histiocytomas

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOI IHC Initial, Tech Only No No
IHTOA IHC Additional, Tech Only No No

Method Name

Immunohistochemistry (IHC)

Reporting Name

Factor 13a IHC, Tech Only

Specimen Type

TECHONLY

Specimen Stability Information

Specimen Type Temperature Time Special Container
TECHONLY Ambient (preferred)
  Refrigerated 

Clinical Information

Factor XIIIa, a blood and intracellularly produced coagulation factor, has been found in a variety of cell types, including fibroblast-like mesenchymal cells, and has been shown to stimulate the proliferation of fibroblasts and neoplastic cells in vitro. Immunohistochemical staining for factor XIIIa labels normal dermal dendrocytes, the large stellate fibroblasts found in acquired digital fibrokeratomas, angiofibromas, and oral fibroma, and a proportion of cells in histiocytomas. Factor XIIIa immunostain also produces cytoplasmic staining of dermal dendrocytes in normal skin and of a proportion of cells in histiocytomas.

Interpretation

This test does not include pathologist interpretation; only technical performance of the stain. If interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.

 

The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request, call 855-516-8404.

 

Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Clinical Reference

1. West KL, Cardona DM, Su Z, Puri PK: Immunohistochemical markers in fibrohistiocytic lesions: factor XIIIa, CD34, S-100 and p75. Am J Dermatopathol. 2014 May;36(5):414-419. doi: 10.1097/DAD.0b013e3182a70396

2. de Alvarenga Lira ML, Pagliari C, de Lima Silva AA, de Andrade HF Jr, Duarte MI: Dermal dendrocytes FXIIIa+ are essential antigen-presenting cells in indeterminate leprosy. Am J Dermatopathol. 2015 Apr;37(4):269-273. doi: 10.1097/DAD.0000000000000238

3. Hirai KE, Aarao TL, Silva LM, et al: Langerhans cells (CD1a and CD207), dermal dendrocytes (FXIIIa) and plasmacytoid dendritic cells (CD123) in skin lesions of leprosy patients. Microb Pathog. 2016 Feb;91:18-25. doi: 10.1016/j.micpath.2015.11.013

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FC13A Factor 13a IHC, Tech Only Order only;no result

 

Result ID Test Result Name Result LOINC Value
70741 Factor 13a IHC, Tech Only Bill only; no result

Forms

If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.

Testing Algorithm

For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI). For each additional technical component only IHC stain performed, an additional bill-only test ID will be reflexed and charged (IHTOA).

Mayo Clinic Laboratories | IHC Catalog Additional Information:

mcl-ihc