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Test ID GRH Growth Hormone Immunostain, Technical Component Only

Ordering Guidance

This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.

Shipping Instructions

Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.

Specimen Required

Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Container/Tube: Immunostain Technical Only Envelope

Preferred: 2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4- microns thick

Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block

Useful For

Aids in the identification of growth hormone adenomas

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOI IHC Initial, Tech Only No No
IHTOA IHC Additional, Tech Only No No

Method Name


Reporting Name

Growth Hormone IHC, Tech Only

Specimen Type


Specimen Stability Information

Specimen Type Temperature Time Special Container
TECHONLY Ambient (preferred)

Clinical Information

Growth hormone (GH) is a 21-kD polypeptide hormone that stimulates protein synthesis and may act primarily via the somatomedins. Somatotroph cells produce GH and constitute a high proportion of anterior pituitary cells (50%). GH shows cytoplasmic staining of normal pituitary somatotroph cells and GH adenomas. Globular juxtanuclear staining may be present in some adenomas.


This test does not include pathologist interpretation; only technical performance of the stain. If interpretation is required order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.


The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Clinical Reference

1. Lea RW, Dawson T, Martinez-Moreno CG, El-Abry N, Harvey S: Growth hormone and cancer: GH production and action in glioma? Gen Comp Endocrinol. 2015 Sep 1;220:119-123. doi: 10.1016/j.ygcen.2015.06.011

2. Mete O, Cintosun A, Pressman I, Asa SL: Epidemiology and biomarker profile of pituitary adenohypophysial tumors. Mod Pathol. 2018 Jun;31(6):900-909. doi: 10.1038/s41379-018-0016-8

3. Proudan N, Peroski M, Grignol G, Merchenthaler I, Dudas B: Juxtapositions between the somatostatinergic and growth hormone-releasing hormone (GHRH) neurons in the human hypothalamus. Neuroscience. 2015 Jun 25;297:205-210. doi: 10.1016/j.neuroscience.2015.03.054

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

LOINC Code Information

Test ID Test Order Name Order LOINC Value
GRH Growth Hormone IHC, Tech Only Order only;no result


Result ID Test Result Name Result LOINC Value
70757 Growth Hormone IHC, Tech Only Bill only; no result


If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.

Testing Algorithm

For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI). For each additional technical component only IHC stain performed, an additional bill-only test ID will be reflexed and charged (IHTOA).

Mayo Clinic Laboratories | IHC Catalog Additional Information: