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Test ID HCG Human Chorionic Gonadotropin (hCG) Immunostain, Technical Component Only

Ordering Guidance

This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.

Shipping Instructions

Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.

Specimen Required

Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Container/Tube: Immunostain Technical Only Envelope

Preferred: 2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick

Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block

Useful For

Identification human chorionic gonadotropin expression in neoplasms

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOI IHC Initial, Tech Only No No
IHTOA IHC Additional, Tech Only No No

Method Name

Immunohistochemistry (IHC)

Reporting Name

Chorion Gonadotropin IHC, Tech Only

Specimen Type


Specimen Stability Information

Specimen Type Temperature Time Special Container
TECHONLY Ambient (preferred)

Clinical Information

Human chorionic gonadotropin (hCG) is produced by the syncytiotrophoblasts of the placenta and has the same biologic properties as pituitary luteinizing hormone (LH). hCG stimulates androgen and progesterone production in women and helps maintain the corpus luteum of pregnancy. hCG is a heterodimeric hormone of 36kD with subunits designated alpha and beta. Many neoplasms including choriocarcinomas and adenocarcinomas may express hCG.


This test does not includes pathologist interpretation; only technical performance of the stain. If an interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.


The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request, call 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Clinical Reference

1. Lenhard M, Tsvilina A, Schumacher L, et al: Human chorionic gonadotropin and its relation to grade, stage and patient survival in ovarian cancer. BMC Cancer. 2012 Jan;12:2. doi: 10.1186/1471-2407-12-2

2. Mustafa A, Bozdag Z, Tepe NB, Ozcan HC: An unexpected reason for elevated human chorionic gonadotropin in a young woman. Cervical squamous carcinoma. Saudi Med J. 2016 Jul 31;37(8):905-907. doi: 10.15537/2016.8.14529

3. Khattri S, Vivekanandarajah A, Varma S, Kong F: Secretion of beta-human chorionic gonadotropin by non-small cell lung cancer: a case report. J Med Case Rep. 2011 Jan;5:19. doi: 10.1186/1752-1947-5-19

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HCG Chorion Gonadotropin IHC, Tech Only Order only;no result


Result ID Test Result Name Result LOINC Value
70768 Chorion Gonadotropin IHC, Tech Only Bill only; no result


If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.

Testing Algorithm

For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI). For each additional technical component only IHC stain performed, an additional bill-only test ID will be reflexed and charged (IHTOA).

Mayo Clinic Laboratories | IHC Catalog Additional Information: