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Test ID HPVLR Human Papillomavirus (HPV) Low Risk, In Situ Hybridization

Shipping Instructions

Attach the green pathology address label included in the kit to the outside of the transport container.

Necessary Information

A pathology/diagnostic report and a brief history are required.

Specimen Required

Supplies: Pathology Packaging Kit (T554)

Specimen Type: Formalin-fixed, paraffin-embedded tissue block

Specimen Volume: Entire block

Specimen Type: Slides

Slides: 5 unstained glass, positively charged slides with 5 (+ or - 1) microns formalin-fixed, paraffin-embedded tissue


If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Oncology Test Request (T729)

-Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763)

Useful For

Detection of human papillomavirus from low-risk genotypes (6, 11)

Method Name

In Situ Hybridization

Reporting Name

HPV Low-Risk ISH

Specimen Type


Specimen Stability Information

Specimen Type Temperature Time Special Container
Special Ambient (preferred)

Clinical Information

Human papillomavirus infections with low-risk genotypes (6, 11) can cause benign hyperplasia such as condylomas and papillomas.


This test, when not accompanied by a pathology consultation request, will be answered as either positive or negative. If additional interpretation or analysis is needed, request PATHC / Pathology Consultation along with this test.

Clinical Reference

1. Kelesidis T, Aish L, Steller MA, et al: Human papillomavirus (HPV) detection using in situ hybridization in histologic samples: correlations with cytologic changes and polymerase chain reaction HPV detection. Am J Clin Pathol. 2011 Jul;136(1):119-127. doi: 10.1309/AJCP03HUQYZMWATP

2. Lee WT, Tubbs RR, Teker AM, et al: Use of in situ hybridization to detect human papillomavirus in head and neck squamous cell carcinoma patients without a history of alcohol or tobacco use. Arch Pathol Lab Med. 2008 Oct;132(10):1653-1656. doi: 10.5858/2008-132-1653-UOISHT

3. Birner P, Bachtiary B, Dreier B, et al: Signal-amplified colorimetric in situ hybridization for assessment of human papillomavirus infection in cervical lesions. Mod Pathol. 2001 Jul;14(7):702-709. doi: 10.1038/modpathol.3880375

Day(s) Performed

Monday through Friday

Report Available

5 to 7 days

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


88364-If additional in situ hybridization

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HPVLR HPV Low-Risk ISH In Process


Result ID Test Result Name Result LOINC Value
71204 Interpretation 50595-8
71205 Participated in the Interpretation No LOINC Needed
71206 Report electronically signed by 19139-5
71208 Material Received 81178-6
71595 Disclaimer 62364-5
72113 Case Number 80398-1
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