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Test ID KI67P Ki-67(MIB-1), Pulmonary, Quantitative Immunohistochemistry, Automated


Shipping Instructions


Attach the green pathology address label included in the kit to the outside of the transport container.



Necessary Information


1. Pathologist's name, address, and phone number are required.

2. Include accompanying pathology report stating the final diagnosis.



Specimen Required


Supplies: Pathology Packaging Kit (T554)

Specimen Type:

Preferred: Formalin-fixed, paraffin-embedded tissue block containing carcinoid/atypical carcinoid tumor of the lung including metastases.

Acceptable: 2 Unstained sections containing carcinoid/atypical carcinoid tumor of the lung including metastases on charged slides cut at 4 microns <1 month ago. Tissue on the slides should have been fixed in 10% neutral buffered formalin.

Container/Tube: Pathology Packaging Kit

Collection Instructions:

1. Submit formalin-fixed, paraffin-embedded tissue block.

2. Attach the green pathology address label included in the kit to the outside of the transport container.

Additional Information: Paraffin block will be returned with the final report.


Useful For

Determining proliferation of tumor cells in paraffin-embedded tissue blocks from patients diagnosed with carcinoid or atypical carcinoid of the lung including metastases

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
KIPM Ki67 Pulmonary IHC Manual No No

Testing Algorithm

Cases that are unable to be scanned for automated analysis will be changed to KIPM / Ki-67(MIB-1), Pulmonary, Quantitative Immunohistochemistry, Manual.

Method Name

Immunohistochemistry, Automated Quantitation, Hot-Spot Technique

Reporting Name

Ki67 Pulmonary IHC Automated

Specimen Type

Special

Specimen Stability Information

Specimen Type Temperature Time Special Container
Special Ambient (preferred)
  Refrigerated 

Clinical Information

Ki-67(MIB-1 clone) is a monoclonal antibody that reacts with cells undergoing DNA synthesis by binding to the Ki-67 antigen, a marker known to be expressed only in proliferating cells. By measuring the amount of tumor cells expressing Ki-67, an estimate of DNA synthesis can be determined. Studies suggest that Ki-67(MIB-1) analysis of paraffin-embedded tissue specimens may provide useful prognostic information in various tumor types.

Reference Values

Varies by tumor type; values reported from 0% to 100%

Interpretation

Results will be reported as a percentage of tumor cells staining positive for Ki-67(MIB-1). Quantitative Ki-67(MIB-1) results should be interpreted within the clinical context for which the test was ordered.

Clinical Reference

Boland JM, Kroneman TN, Jenkins SM, et al: Ki-67 Labeling index in pulmonary carcinoid tumors: Comparison between small biopsy and resection using tumor tracing and hot spot methods. Arch Pathol Lab Med. 2020 Jan 16;144(8):982-990

Day(s) Performed

Monday through Friday

Report Available

4 to 6 days

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

88361

LOINC Code Information

Test ID Test Order Name Order LOINC Value
KI67P Ki67 Pulmonary IHC Automated In Process

 

Result ID Test Result Name Result LOINC Value
72132 Interpretation 29593-1
72133 Participated in the Interpretation No LOINC Needed
72134 Report electronically signed by 19139-5
72135 Material Received 81178-6
72136 Disclaimer 62364-5
72137 Case Number 80398-1

Forms

If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.

Mayo Clinic Laboratories | IHC Catalog Additional Information:

mcl-ihc-interp