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Test ID LYSOZ Lysozyme Immunostain, Technical Component Only

Ordering Guidance

This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.

Shipping Instructions

Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.

Specimen Required

Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Preferred: 2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.

Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block

Useful For

Aids in confirmation of monocytic and histiocytic differentiation

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOI IHC Initial, Tech Only No No
IHTOA IHC Additional, Tech Only No No

Method Name


Reporting Name

Lysozyme IHC, Tech Only

Specimen Type


Specimen Stability Information

Specimen Type Temperature Time Special Container
TECHONLY Ambient (preferred)

Clinical Information

Lysozyme is an intracellular enzyme found in the primary granules of myeloid cells, monocytes, and histiocytes. Diagnostically, antibodies to lysozyme can help confirm monocytic and histiocytic differentiation in acute myeloid leukemia or histiocytic sarcoma.


This test includes only technical performance of the stain (no pathologist interpretation is performed). Mayo Clinic cannot provide an interpretation of tech only stains outside the context of a pathology consultation. If an interpretation is needed, refer to PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case. All material associated with the case is required. Additional specific stains may be requested as part of the pathology consultation, and will be performed as necessary at the discretion of the Mayo pathologist.


The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Clinical Reference

1. Burgdorf WH, Duray P, Rosai J: Immunohistochemical Identification of Lysozyme in Cutaneous Lesions of Alleged Histiocytic Nature. Am J Clin Pathol 1981;75(2):162-167

2. Kurec AS, Cruz VE, Barrett D, et al: Immunophenotyping of Acute Leukemias Using Paraffin-Embedded Tissue Sections. Am J Clin Pathol 1990;93(4):502-509

3. Li WV, Kapadia SB, Sonmez-Alpan E, Swerdlow SH: Immunohistochemical Characterization of Mast Cell Disease in Paraffin Sections Using Tryptase, CD68, Myeloperoxidase, Lysozyme, and CD20 Antibodies. Modern Pathology 1996;9(10):982-988

4. Miettinen M, Fetsch JF: Reticulohistiocytoma (Solitary Epithelioid Histiocytoma). A Clinicopathologic and Immunohistochemical Study of 44 Cases. Am J Surg Pathol 2006;30:521-528

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

LOINC Code Information

Test ID Test Order Name Order LOINC Value
LYSOZ Lysozyme IHC, Tech Only Order only;no result


Result ID Test Result Name Result LOINC Value
70815 Lysozyme IHC, Tech Only Bill only; no result


If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.

Testing Algorithm

For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI). For each additional technical component only IHC stain performed, an additional bill-only test ID will be reflexed and charged (IHTOA).

Mayo Clinic Laboratories | IHC Catalog Additional Information: