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Test ID MUCN4 Mucin 4, Immunostain, Technical Component Only


Ordering Guidance


This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.



Shipping Instructions


Attach the green pathology address label and the pink Immunostains Technical Only label included in the kit to the outside of the transport container.



Specimen Required


Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Preferred: 2 unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.

Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block


Useful For

Aids in the differentiation of sarcomatoid carcinoma from sarcomatoid mesothelioma

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOI IHC Initial, Tech Only No No
IHTOA IHC Additional, Tech Only No No

Method Name

Immunohistochemistry

Reporting Name

Mucin 4 IHC, Tech Only

Specimen Type

TECHONLY

Specimen Stability Information

Specimen Type Temperature Time Special Container
TECHONLY Ambient (preferred)
  Refrigerated 

Clinical Information

Mucin 4 (MUC4) is a large membrane-anchored glycoprotein that belongs to the mucin family. Mucins play important roles in the protection of epithelial cells and have been implicated in epithelial renewal and differentiation. MUC4 is expressed in the cytoplasm and membrane of respiratory, gastrointestinal, cervical, and prostatic epithelial cells. Overexpression of MUC4 has been observed in many carcinomas. It has been shown to be useful for the distinction between sarcomatoid carcinoma (often expressed) versus sarcomatoid mesothelioma (usually negative).

Interpretation

This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.

 

The positive and negative controls are verified as showing appropriate immunoreactivity. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.

 

Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Clinical Reference

1. Tamura Y, Higashi M, Kitamoto S, et al: MUC4 and MUC1 expression in adenocarcinoma of the stomach correlates with vessel invasion and lymph node metastasis: an immunohistochemical study of early gastric cancer. PLoS One 2012; 7(11):e49251

2. Kwon K, Ro J, Singhal N, et al: MUC4 expression in non-small cell lung carcinomas: relationship to tumor histology and patient survival. Arch Pathol Lab Med 2007 Apr;131(4):593-598

3. Majhi PD, Lakshmanan I, Ponnusamy M, et al: Pathobiological implications of MUC4 in non-small-cell lung cancer. J Thorac Oncol 2013 Apr;8(4):398-407

4. Cowan M, Thompson L, Leon M, et al: Low-Grade Fibromyxoid Sarcoma of the Head and Neck: A Clinicopathologic Series and Review of the Literature. Head Neck Pathol 2016 Jun;10(2):161-166

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MUCN4 Mucin 4 IHC, Tech Only Order only;no result

 

Result ID Test Result Name Result LOINC Value
601741 Mucin 4 IHC, Tech Only Bill only; no result

Forms

If not ordering electronically, complete, print, and send an Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.

Mayo Clinic Laboratories | IHC Catalog Additional Information:

mcl-ihc