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Test ID MYPO Myeloperoxidase (MPO) Immunostain, Technical Component Only

Ordering Guidance

This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.

Shipping Instructions

Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.

Specimen Required

Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Container/Tube: Immunostain Technical Only Envelope

Preferred: 2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.

Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block

Useful For

A marker of myeloid lineage

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOI IHC Initial, Tech Only No No
IHTOA IHC Additional, Tech Only No No

Method Name

Immunohistochemistry (IHC)

Reporting Name

Myeloperoxidase IHC, Tech Only

Specimen Type


Specimen Stability Information

Specimen Type Temperature Time Special Container
TECHONLY Ambient (preferred)

Clinical Information

Myeloperoxidase shows strong cytoplasmic immunoreactivity in neutrophilic and eosinophilic granulocytes and their precursors. Virtually all other cell types are negative for myeloperoxidase staining. Antibodies to myeloperoxidase are most useful diagnostically to support myeloid lineage in acute leukemias. These antibodies also facilitate the detection of granulocyte precursors in myeloproliferative disorders and myelodysplastic syndromes.


This test does not include pathologist interpretation, only technical performance of the stain. If interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.


The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request, call 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Clinical Reference

1. Chuang SS, Li CY: Useful panel of antibodies for the classification of acute leukemia by immunohistochemical methods in bone marrow trephine biopsy specimens. Am J Clin Pathol. 1997;107(4):410-418. doi: 10.1093/ajcp/107.4.410

2. Li WV, Kapadia SB, Sonmez-Alpan E, Swerdlow SH: Immunohistochemical characterization of mast cell disease in paraffin sections using tryptase, CD68, myeloperoxidase, lysozyme, and CD20 antibodies. Mod Pathol. 1996;9(10):982-988

3. Liu W, Hasserjian RP, Hu Y, et al: Pure erythroid leukemia: A reassessment of the entity using the 2008 World Health Organization classification. Mod Pathol. 2011;24:375-383. doi: 10.1038/modpathol.2010.194

4. O;Malley DP, Young SK, Perkins SL, Baldridge L, Juliar BE, Orazi A: Morphologic and immunohistochemical evaluation of splenic hematopoietic proliferations in neoplastic and benign disorders. Mod Pathol. 2005;18:1550-1561. doi: 10.1038/modpathol.3800480

5. Pileri SA, Ascani S, Milani M, et al: Acute leukaemia immunophenotyping in bone-marrow routine sections. Br J Hematol .1999;105:394-401

6. Gao L, Lu GT, Lu YY, et al: Diabetes aggravates acute pancreatitis possibly via activation of NLRP3 inflammasome in db/db mice. Am J Transl Res. 2018 Jul 15;10(7):2015-2025

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MYPO Myeloperoxidase IHC, Tech Only Order only;no result


Result ID Test Result Name Result LOINC Value
70823 Myeloperoxidase IHC, Tech Only Bill only; no result


If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.

Mayo Clinic Laboratories | IHC Catalog Additional Information: