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Test ID PTH Parathyroid Hormone (PTH) Immunostain, Technical Component Only


Ordering Guidance


This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.



Shipping Instructions


Attach the green "Attention Pathology" address label (T498) and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.



Specimen Required


Specimen Type: Tissue

Supplies: Immunostain Technical Only Envelope (T693)

Container/Tube: Immunostain Technical Only Envelope

Preferred:

-Formalin-fixed, paraffin-embedded tissue block

OR

-2 Unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick

Acceptable: None


Useful For

Identification of parathyroid glands

Disease States

  • Hyperparathyroidism

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOI IHC Initial, Tech Only No No
IHTOA IHC Additional, Tech Only No No

Method Name

Immunohistochemistry (IHC)

Reporting Name

Parathyroid Hormone IHC, Tech Only

Specimen Type

TECHONLY

Specimen Stability Information

Specimen Type Temperature Time Special Container
TECHONLY Ambient (preferred)
  Refrigerated 

Clinical Information

Parathyroid hormone staining is useful in identifying parathyroid glands in cases of hyperparathyroidism. Hyperproduction of parathyroid-like hormone may occur in association with lung tumors; such tumors may have reactivity with parathyroid hormone antibodies.

Interpretation

This test does not include pathologist interpretation, only technical performance of the stain. If interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.

 

The positive and negative controls are verified as showing appropriate immunoreactivity. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request; call 855-516-8404.

 

Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Clinical Reference

1. Matsushita H, Usui M, Hara Y, et al. Co-secretion of parathyroid hormone and parathyroid-hormone-related protein via a regulated pathway in human parathyroid adenoma cells. Am J Pathol. 1997;150(3):661-871

2. Oka T, Yoshioka T, Shrestha GR, et al. Immunohistochemical study of nodular hyperplastic parathyroid glands in patients with secondary hyperparathyroidism. Virchows Arch A Pathol Anat Histopathol. 1988;413(1):53-60

3. Wick MR, Ritter JH, Humphrey PA, Nappi O. Clear cell neoplasms of the endocrine system and thymus. Semin Diagn Pathol. 1997;14(3):183-202

4. Sass MR, Wewer Albrechtsen NJ, Pedersen J, et al. Secretion of parathyroid hormone may be coupled to insulin secretion in humans. Endocr Connect. 2020;9(7):747-754. doi:10.1530/EC-20-0092

5. Magaki S, Hojat SA, Wei B, So A, Yong WH. An introduction to the performance of immunohistochemistry. Methods Mol Biol. 2019;1897:289-298. doi:10.1007/978-1-4939-8935-5_25

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PTH Parathyroid Hormone IHC, Tech Only Order only;no result

 

Result ID Test Result Name Result LOINC Value
70856 Parathyroid Hormone IHC, Tech Only Bill only; no result

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763)

-Renal Diagnostics Test Request (T830)

Mayo Clinic Laboratories | IHC Catalog Additional Information:

mcl-ihc