Sign in →

Test ID SOMAT Somatostatin Immunostain, Technical Component Only

Ordering Guidance

This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.

Shipping Instructions

Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.

Specimen Required

Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Container/Tube: Immunostain Technical Only Envelope (T693)

Preferred: 2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.

Acceptable: Formalin-fixed, paraffin-embedded tissue block

Useful For

Aids in the characterization of pancreatic islet cell tumors or other neuroendocrine tumors

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOI IHC Initial, Tech Only No No
IHTOA IHC Additional, Tech Only No No

Method Name

Immunohistochemistry (IHC)

Reporting Name

Somatostatin IHC, Tech Only

Specimen Type


Specimen Stability Information

Specimen Type Temperature Time Special Container
TECHONLY Ambient (preferred)

Clinical Information

Somatostatin is a cyclic polypeptide hormone originally isolated from the hypothalamus and characterized by its ability to inhibit the release of growth hormone from the pituitary. In the digestive system, somatostatin production occurs in the intrinsic nerves of the intestinal wall, endocrine cells of the digestive mucosa, and in the D-cells of pancreatic islets. Antibodies to somatostatin can be used to characterize pancreatic islet cell tumors or other neuroendocrine tumors.


This test does not include pathologist interpretation, only technical performance of the stain. If interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.


The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request; call 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Clinical Reference

1. Govindaraian Me, Mohan V, Deepa R, et al: Histopathology and immunohistochemistry of pancreatic islets in fibrocalculous pancreatic diabetes. Diabetes Res Clin Pract. 2001 Jan;51(1):29-38

2. Kasacka I, Lebkowski W, Janiuk I, et al: Immunohistochemical identification and localisation of gastrin and somatostatin in endocrine cells of human pyloric gastric mucosa. Folia Morphol. 2012 Feb;71(1):39-44

3. Sporrong B, Falkmer S, Robboy SJ, et al: Neurohormonal peptides in ovarian carcinoids: an immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six mid-gut carcinoids. Cancer 1982 Jan 1;49(1):68-74

4. Zalatnai A, Galambos, E, Perjesi, E: Importance of immunohistochemical detection of somatostatin receptors. Pathol Oncol Res. 2019 Apr;25(2):521-525. doi: 10.1007/s12253-018-0426-4

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SOMAT Somatostatin IHC, Tech Only Order only;no result


Result ID Test Result Name Result LOINC Value
70865 Somatostatin IHC, Tech Only Bill only; no result


If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.

Mayo Clinic Laboratories | IHC Catalog Additional Information: